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Write 4 page essay on the topic Research project: Maternal influenza immunization. The immunization process is explored from two main aspects: the immunogenicity of pneumococcal vaccines, as pneumonia is one of the most severe complications of influenza infections in infants and mothers, and the clinical effectiveness of the influenza vaccine. This represent a prospective, controlled, blinded, randomized trial, where the pneumococcal vaccine is given to a group of mothers, some who have received the influenza vaccine, and others that have not. At the same time no infants should receive the influence vaccine. In this study, infected infants will be considered those of age less than 24 weeks and have a positive influenza laboratory result. Clinician-confirmed cases and swabs taken from infants for influenza-antigen testing will also be considered. Respiratory illness with fever or of documented fever of more than 38°C, clinic visits with respiratory illness, and episodes of diarrhea found in both mothers and infants will be considered. The number of cases will show the effectiveness of the influenza vaccines, as well as pneumococcal vaccine, as well as the combination of both, to give us a more clear picture of the effectiveness of immunization. Mothers that have had complicated pregnancies and deliveries, abortions and hypersensitivity to the vaccines will be excluded from the project. The mothers used in the project should provide a signed consent form, and, when considering the pneumococcal vaccine, then they are assigned in one of four groups. The first two groups would receive the pneumococcal vaccine, while in the second two groups, the mother will receive the influenza vaccine only. When the influenza vaccination is concerned, the subjects are placed and analyzed in two groups: the control group and the group that received the influenza vaccine. Using a computer, the subjects are randomized and placed in the specific groups. Blood samples are also taken from mother before and after immunization.


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